Cisplatin is associated with which toxicities?

Cisplatin is associated with which toxicities?

• A. Nephrotoxicity
• B. Nephrotoxicity and ototoxicity
• C. Neurotoxicity
• D. Cardiotoxicity

Answer: (B)

Cisplatin’s toxicity profile centers on two hallmark effects: kidney injury and ear toxicity. It tends to accumulate in renal tubular cells, causing proximal tubule damage that leads to nephrotoxicity. This is a major dose-limiting toxicity and is best mitigated with aggressive IV hydration and, in some cases, protective agents like amifostine. Ototoxicity results from cisplatin damaging the sensory hair cells in the cochlea, producing bilateral, often irreversible high-frequency hearing loss. The risk rises with higher cumulative doses and is a well-recognized, characteristic side effect. Neurotoxicity can occur, but it’s not as defining or as common as the kidney and ear toxicities. Cardiotoxicity is not typical for cisplatin, unlike some other chemotherapies. So, nephrotoxicity and ototoxicity together best reflect the classic cisplatin toxicity profile.

Cisplatin’s toxicity profile centers on two hallmark effects: kidney injury and ear toxicity. It tends to accumulate in renal tubular cells, causing proximal tubule damage that leads to nephrotoxicity. This is a major dose-limiting toxicity and is best mitigated with aggressive IV hydration and, in some cases, protective agents like amifostine.

Ototoxicity results from cisplatin damaging the sensory hair cells in the cochlea, producing bilateral, often irreversible high-frequency hearing loss. The risk rises with higher cumulative doses and is a well-recognized, characteristic side effect.

Neurotoxicity can occur, but it’s not as defining or as common as the kidney and ear toxicities. Cardiotoxicity is not typical for cisplatin, unlike some other chemotherapies.

So, nephrotoxicity and ototoxicity together best reflect the classic cisplatin toxicity profile.